Papers

31.
Valencia, P.; Basto, P., Zhang, L.; Langer, R.; Farokhzad, O. C.; Karnik, R. "Single-step assembly of homogeneous lipid-polymeric and lipid-quantum dots nanoparticles enabled by microfluidic rapid mixing", ACS Nano 2010, in press.
30.
Nakatsuji, T.; Kao, M. C.; Zhang, L.; Zouboulis, C. C.; Gallo, R. L.; Huang, C-M. "Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating ß-defensin-2 expression", Journal of Investigative Dermatology 2010, in press.
29.
Chan, J.; Zhang, L.; Tong, R.; Ghosh, D.; Gao, W.; Liao, G.; Yuet, K.; Gray, D.; Rhee, J-W.; Cheng, J.; Golomb, G.; Libby, P.; Langer, R.; Farokhzad, O. C. "Spatiotemporal controlled delivery of nanoparticles to injured vasculature", Proceedings of the National Academy of Sciences 2010, 107, 2213-2218. [pdf]
28.
Aryal, S.; Hu, C-M.; Zhang, L.* "Polymer-cisplatin conjugate nanoparticles for acid-responsive drug delivery", ACS Nano 2010, 4, 251-258. [pdf]
27.
Zhang, L.*; Pornpattananangkul, D.; Hu, C-M.; Huang, C-M. "Development of nanoparticles for antimicrobial drug delivery", Current Medicinal Chemistry 2010, 17, 585-594.
26.
Chan, J.; Valencia, M. P.; Zhang, L.; Langer, R.; Farokhzad, O. C. "Polymer nanoparticles for drug delivery" in Cancer Nanotechnology: Methods and Protocols (Grobmyer, S. and Moudgil, B., Eds.), Springer Press, USA, 2010.
25.
Hu, C-M.; Zhang, L.* "Therapeutic nanoparticles to combat cancer drug resistance", Current Drug Metabolism 2009, 10, 836-841.
24.
Mora, L.; Chumbimuni-Torres, K. Y.; Clawson, C.; Hernandez, L.; Zhang, L.*; Wang, J. "Real-time electrochemical monitoring of drug release from therapeutic nanoparticles", Journal of Controlled Release 2009, 140, 69-73. [pdf]
23.
Yang, D.; Pornpattananangkul, D.; Nakatsuji, T.; Chan, M.; Carson, D.; Huang, C-M.; Zhang, L.* "The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes", Biomaterials 2009, 30, 6035-6040. [pdf]
22.
Nakatsuji, T.; Kao, M. C.; Fang, J-Y.; Zouboulis, C. C.; Zhang, L.; Gallo, R. L.; Huang, C-M. "Antimicrobial property of lauric acid against propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris", Journal of Investigative Dermatology 2009, 129, 2480-2488. [pdf]
21.
Salvador-Morales, C.; Zhang, L.; Langer, R.; Farokhzad, O. C. "Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups", Biomaterials 2009, 30, 2231-2240. [pdf]
20.
Chan, J.; Zhang, L.; Yuet, K.; Liao, G.; Rhee, J-W.; Langer, R.; Farokhzad, O. C. "PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery", Biomaterials 2009, 30, 1627-1634. [pdf]
19.
Alexis, F.; Basto, P.; Levy-Nissenbaum, E.; Radovic-Moreno, A.; Zhang, L.; Pridgen, E.; Wang, A.; Molnar, S.; Westerhof K.; Farokhzad, O. C. "HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy", ChemMedChem 2008, 3, 1839-1843. [pdf]
18.
Wang, B.; Zhang, L.; Bae, S. C.; Granick, S. "Nanoparticle-induced surface reconstruction of phospholipid membranes", Proceedings of the National Academy of Sciences 2008, 105, 18171-18175. [pdf]
Highlighted: Nature Nanotechnology 2008, doi:10.1038/nnano.2008.371. [link]
17.
Wang, A.; Bagalkot, V.; Vasilliou, C.; Gu. F.; Alexis, F.; Zhang, L.; Shaikh, M. R.; Yuet, K.; Cima, M.; Langer, R.; Kantoff, P. W.; Bander, N. H.; Jon, S.; Farokhzad, O. C. "Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy", ChemMedChem 2008, 3, 1311-1315. [pdf]
16.
Zhang, L. ; Chan, J.; Gu, F.; Rhee, J-W.; Wang, A.; Radovic-Moreno, A.; Alexis, F.; Langer, R.; Farokhzad, O. C. "Self-assembled lipid-polymer hybrid nanoparticles: A robust drug delivery platform", ACS Nano 2008, 2, 1696-1702. [pdf]
15.
Wang, A.; Gu, F.; Zhang, L.; Chan, J.; Radovic-Modovic, A.; Shaikh, M. R.; Farokhzad, O. C. "Biofunctionalized targeted nanoparticles for therapeutic applications", Expert Opinion on Biological Therapy 2008, 8, 1063-1070. [pdf]
14.
Zhang, L.; Gu, F.; Chan, J.; Wang, A.; Langer, R.; Farokhzad, O. C. "Nanoparticles in medicine: Therapeutic applications and developments", Clinical Pharmacology & Therapeutics 2008, 83, 761-769. [pdf]
13.
Gu, F.; Zhang, L.; Teply, B.; Mann, N.; Wang, A.; Radovic-Moreno, A.; Langer, R.; Farokhzad, O. C. "Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers", Proceedings of the National Academy of Sciences 2008, 105, 2586-2591. [pdf]
12.
Bagalkot, V.; Zhang, L.; Levy-Nissenbaum, E.; Jon, S.; Kantoff, P. W.; Langer, R.; Farokhzad, O. C. "Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy and sensing of drug delivery based on bi-fluorescence resonance energy transfer", Nano Letters 2007, 7, 3065-3070. [pdf]
11.
Zhang, L.; Radovic-Moreno, A.; Alexis, F.; Gu, F.; Basto, P. A.; Bagalkot, V.; Jon, S.; Langer, R.; Farokhzad, O. C. "Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates", ChemMedChem 2007, 2, 1268-1271. [pdf]
10.
Yu, Y.; Anthony, S.; Zhang, L.; Bae, S. C.; Granick, S. "Cationic nanoparticles stabilize zwitterionic liposomes better than anionic ones", Journal of Physical Chemistry C 2007, 111, 8233-8236. [pdf]
9.
Zhang, L.; Dammann, K.; Bae, S. C. Granick, S. "Ligand-receptor binding on nanoparticle-stabilized liposome surfaces", Soft Matter 2007, 3, 551-553. [pdf]
8.
Zhang, L.; Granick, S. "Inter-leaflet diffusion coupling when polymer adsorbs onto one sole leaflet of a supported phospholipid bilayer", Macromolecules 2007, 40, 1366-1368. [pdf]
7.
Zhang, L.; Hong, L.; Yu, Y.; Bae, S. C.; Granick, S. "Nanoparticle-assisted surface immobilization of phospholipid liposomes", Journal of the American Chemical Society 2006, 128, 9026-9027. [pdf]
6.
Zhang, L.; Granick, S. "Dynamical heterogeneity in supported lipid bilayers", MRS Bulletin 2006, 31, 527-531. [pdf]
5.
Anthony, S.; Zhang, L.; Granick, S. "Methods to track single-molecule trajectories", Langmuir 2006, 22, 5266-5272. [pdf]
4.
Zhang, L.; Granick, S. "How to stabilize phospholipid liposomes (using nanoparticles)", Nano Letters 2006, 6, 694-698. [pdf]
Highlighted: Science 2006, 311, 1347. [pdf]; Nature Materials 2006, 5, 249. [pdf]
3.
Zhang, L.; Spurlin, T. A.; Gewirth, A. A.; Granick, S. "Electrostatic stitching in gel-phase supported phospholipid bilayers", Journal of Physical Chemistry B 2006, 110, 33-35. [pdf]
Highlighted: Science 2005, 310, 1871. [pdf]
2.
Zhang, L.; Granick, S. "Lipid diffusion compared in outer and inner leaflets of planar supported bilayers", Journal of Chemical Physics 2005, 123, 211104/1-4. [pdf]
1.
Zhang, L.; Granick, S. "Slaved diffusion in phospholipid bilayers", Proceedings of the National Academy of Sciences 2005, 102, 9118-9121. [pdf]

Patents

10.
Zhang, L.; Aryal, S.; Kummel, A.; Howell, S. "Platinum compounds and methods of use", US Provisional Patent Application US61/288,742 (2009).
9.
Zhang, L.; Hood, J.; Huang, C-M. "Compositions and methods for treating acne", US Provisional Patent Application, US61/231,210 (2009).
8.
Valencia, P.; Basto, P; Zhang, L.; Farokhzad, O. C.; Langer, R.; Karnik, R. "Microfluidic one-step synthesis of hybrid lipid-polymeric nanoparticles for drug delivery applications", US Provisional Patent Application, US61/104,587 (2009).
7.
Salvador-Morales, C.; Zhang, L.; Farokhzad, O. C.; Langer, R. "Methods to control the levels of complement system activation of lipid-polymer hybrid nanoparticles", International Patent Application (2009).
6.
Wang, A.; Zhang, L.; Gu, F.; Farokhzad, O. C.; Langer, R. "Multifuncitonal nanoparticles for chemoradiotherapy", International Patent Application, PCT/US2008/086255 (2008).
5.
von Andrian, U.; Farokhzad, O.; Langer, R.; Junt, T.; Moseman, A.; Zhang, L.; Basto, P.; Iannacone, M.; Alexis, F. "Vaccine nanotechnology", International Patent Application, PCT/US2008/011938 (2008).
4.
Zhang, L.; Radovic-Moreno, A.; Gu, F.; Alexis, F.; Farokhzad, O. C.; Langer, R. "Amphiphilic compound assisted polymeric particles for targeted delivery", International Patent Application, PCT/US2008/059480 (2008).
3.
Alexis, F.; Zhang, L.; Chan, J.; Basto, P.; Levy-Nissenbaum, E.; Farokhzad O. C.; Langer, R. "Poly(amino acid)- targeted moieties", International Patent Application, PCT/US2008/059491 (2008).
2.
Radovic-Moreno, A.; Zhang, L.; Farokhzad, O. C.; Langer, R. "Polymer-encapsulated reverse micelles", International Patent Application, PCT/US2008/059483 (2008).
1.
Farokhzad, O. C.; Jon, S.; Bagalkot, V.; Zhang, L.; Teply, B.; Levy-Nissenbaum, E.; Langer, R. “Aptamer-directed drug delivery”, International Patent Application, PCT/US2007/069144 (2007).