We work on the design, synthesis, characterization and evaluation of lipid- and polymer-based nanostructured biomaterials. One specific interest lies in developing nanomaterials for healthcare and other medical applications, for example, drug delivery to improve or enable treatments of human diseases. In addition, we also seek to understand the fundamental sciences underlying the arenas of nanomedicine. Overall, our research covers a broad scope of multidisciplinary areas including chemical & molecular engineering, materials science, chemistry, nanotechnology, biotechnology and medicine.
Currently, we are interested in three specific topics: (1) developing multifunctional lipid-polymer hybrid nanoparticles as a robust drug delivery platform that combines the merits of liposomes and polymeric nanoparticles; (2) simultaneously delivering multiple drugs with different hydrophobicity to the same cancer cells for combination therapy; and (3) understanding how single nanoparticles with distinct characteristics interact with biomembranes, with special focus on understanding cellular endocytosis and endosome escape of therapeutic nanoparticles. For detailed description about these projects, you are welcome to visit our group webpage.